In vitro studies with analogs related to ENMD-1420 showed that the Z isomer is more potent than the E isomer for antiproliferative activity. 与ENMD-1420相关的类似物体外研究显示在抗增殖活性方面Z异构体强于E异构体。
A sensitive and specific identification method of E isomer impurity in raw drug of Z cefepime dihydrochloride was established with high performance liquid chromatography/ tandem-time of flight ( HPLC/ ( Q-TOF)) mass spectrometry technology. 采用高效液相色谱/串联质谱技术建立了快速鉴定Z型盐酸头孢吡肟原料药中E型异构体杂质的新方法。
All other metabolites including ( Z)-isomer of RXM exhibited lower antibacterial potency than RXM, except that O-demethyl RXM showed similar antibacterial efficacy to parent drug. 除O-去甲基代谢物与罗红霉素具有相近的抗菌活性外,其他代谢物的抗菌活性均弱于母体药物。